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Fragile X Syndrome
Cannabis for Fragile X Syndrome
Fragile X syndrome is a genetic disorder that can cause a range of developmental problems, most notably autism, learning disabilities and cognitive impairment. Affected individuals delayed development of speech and language by the age of 2. Males are more often affected than females.
Fragile X syndrome is associated with conditions like autism spectrum disorder (AUD), attention deficit disorder (ADD) and attention-deficit hyperactivity disorder (ADHD), and seizure disorders such as epilepsy. Fragile X syndrome is caused by a mutation in the FMR1 gene.
It is theorized that mutations in the FMR1 gene impairs neuronal excitability, meaning signals from the brain aren’t sent properly and/or are sent very slowly. Enhanced endocannabinoid signaling and anandamide production may help treat conditions associated with fragile X syndrome.
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Animal Study
9
Clinical Meta-analysis
1
Clinical Trial
1
Double Blind Clinical Trial
1
Meta-analysis
6
Total studies
Fragile X Syndrome
18
Positive
17 studies
94%
Inconclusive
1 studies
6%
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Relevant studies
The information in our comprehensive A to Z encyclopedia comes from real scientific studies.
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- A phase 1/2, open-label assessment of the safety, tolerability, and efficacy of transdermal cannabidiol (ZYN002) for the treatment of pediatric fragile X syndrome
- A randomized, controlled trial of ZYN002 cannabidiol transdermal gel in children and adolescents with fragile X syndrome (CONNECT-FX)
- A systematic review of cannabidiol dosing in clinical populations
- Cannabidiol and Neurodevelopmental Disorders in Children
- Cannabidiol as a personalized treatment for anxiety: clinical cases in Mexico